產(chǎn)品描述

在生命科學、基礎(chǔ)醫(yī)學及高原生理等研究領(lǐng)域，精確模擬低氧環(huán)境對于探究缺氧對動物機體的影響至關(guān)重要。低氧工作站正是為此類嚴謹動物實驗而設(shè)計的核心設(shè)備。

不同于普通低氧實驗箱在操作時必須開箱破壞環(huán)境，低氧工作站通過其全密閉結(jié)構(gòu)和內(nèi)置操作手套，實現(xiàn)了革命性的突破。研究者無需打開主腔室，即可通過氣密手套在持續(xù)、穩(wěn)定維持目標低氧水平（如1%-21% O?可調(diào)）的環(huán)境下，對箱內(nèi)動物進行各項操作，包括：

?日常照料：安全地進行喂食、飲水更換，確保動物長期實驗中的基本生存需求。

?實驗干預(yù)：執(zhí)行精準的給藥、注射、手術(shù)或生理參數(shù)監(jiān)測（如體溫、心率）。

?行為觀察：在恒定低氧條件下進行動物行為學實驗，減少環(huán)境波動干擾。

?原位采樣：直接在低氧環(huán)境中采集血液、組織等樣本，很大程度避免樣本暴露于常氧環(huán)境導(dǎo)致的氧化應(yīng)激或代謝狀態(tài)改變，保障后續(xù)分析數(shù)據(jù)的真實性。

?設(shè)備操作：放置或操作小型實驗儀器（如微型跑步機、攝像頭）。

核心優(yōu)勢

1、環(huán)境穩(wěn)定性：操作過程“零中斷"低氧環(huán)境，氧氣濃度波動極?。ㄍǔ?lt;±0.1%），為慢性、長期低氧暴露實驗（數(shù)天至數(shù)月）提供持續(xù)、可靠的低氧條件，消除因頻繁開箱導(dǎo)致的濃度回升與恢復(fù)延遲問題。

2、操作便利性與連續(xù)性：無需等待環(huán)境恢復(fù)，可隨時、頻繁地進行實驗操作，極大提升實驗效率和靈活性。

3、減少動物應(yīng)激：密閉操作減少了光線、噪音和人員活動對動物的直接干擾，有助于獲得更接近自然狀態(tài)的生理反應(yīng)數(shù)據(jù)。

4、保障樣本真實性：低氧環(huán)境下的原位采樣和處理，是研究缺氧相關(guān)生物標志物、基因表達和代謝產(chǎn)物的關(guān)鍵保障，避免取樣后氧化造成的假象。

5、集成環(huán)境控制（可選）：高級型號可集成精確的溫濕度控制系統(tǒng)及CO?清除裝置，為動物提供更舒適、生理狀態(tài)更穩(wěn)定的實驗環(huán)境。

6、潔凈度與安全性：密閉設(shè)計結(jié)合高效過濾系統(tǒng)（HEPA/ULPA），可有效控制微生物污染；同時為操作者提供物理屏障，隔絕潛在過敏原或?qū)嶒炐杂泻ξ镔|(zhì)。

應(yīng)用場景

低氧工作站是進行高原適應(yīng)機制研究、缺血性疾病模型、低氧相關(guān)腫瘤研究、低氧與代謝疾病的研究、低氧與心血管疾病的研究、圍生期缺血缺氧性腦損傷以及任何要求在穩(wěn)定低氧環(huán)境下進行活體操作或原位取樣的動物實驗的理想平臺。它克服了傳統(tǒng)低氧箱的核心局限，為獲得嚴謹、可重復(fù)的高質(zhì)量科研數(shù)據(jù)奠定了堅實的基礎(chǔ)。

技術(shù)參數(shù)

1. 為動物低氧實驗?zāi)Ｐ偷慕⑻峁┓€(wěn)定的低氧環(huán)境

2. 按照設(shè)定氣體濃度自動配比氣體，維持恒定的氧氣濃度環(huán)境。無需在箱體外混合比例氣體，實驗氧濃度的準確，節(jié)省氣源

3. 觸摸屏控制，人性化界面，操作簡單

4. 監(jiān)測參數(shù)：溫度、濕度、氧氣濃度、二氧化碳濃度

5. 控制精度：±0.1%

6. 非色散紅外（NDIR）二氧化碳傳感器，測量范圍：0～5000ppm

7. 進口電化學氧氣濃度檢測器，測量范圍：0-25%vol（可選配0.1-99.0%），線性度好，檢測準確、使用壽命長。具有溫度補償機制

8. 溫度檢測：進口高精度溫度傳感器

9. 氧氣濃度變化動態(tài)曲線，直觀了解氧氣濃度變化的過程

10. 內(nèi)置紫外滅菌燈，可定時滅菌

11. 具有定時功能，實驗完成，自動恢復(fù)常氧狀態(tài)，并伴有聲音提示

12. 氧氣濃度自動校準：通過控制器對傳感器快速校準

13.氣體混合及循環(huán)機制，保證箱體內(nèi)氣體濃度的均一

14. 高性能電磁閥，性能穩(wěn)定，超長壽命

15. 前面板可徒手拆卸，便于放置設(shè)備

可選配功能

1、溫度濕度控制功能，控溫范圍：室溫+3~45℃（可選4~45℃），調(diào)節(jié)精度0.1℃；濕度40~85%RH

2、遠程監(jiān)控：可通過電腦、手機遠程監(jiān)控實驗運行狀態(tài)，具有可夜視紅外攝像頭

3、二氧化碳吸附裝置

4、二氧化碳濃度控制功能，可設(shè)定目標濃度，控制范圍：0-20.0%，其他范圍可選

型號選擇

相關(guān)文獻

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[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling".[J]. Archives of Biochemistry and Biophysics ,Volume 729,109393.

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice:Involvement of inhibition of the NF-κB signaling pathway in glial cells".[J].European Journal of Pharmacology,Volume 929,2022,175137.

[4]Jun-Yu Wei,Miao-Yue Hu,Xiu-Qi Chen,Feng-Ying Lei,Jin-Shuang Wei,Jie Chen,Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner".[J]. European Journal of Pharmacology,Renal Failure, 44:1,2056-2065.

[5]Yilan Wang, Zherui Shen, Caixia Pei,Sijing Zhao,Nan Jia, Demei Huang, Xiaomin Wang,Yongcan Wu, Shihua Shi,Yacong He,Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling".[J].Biomedicine & Pharmacotherapy,Volume 156,2022,113982.

[6]Fang Zhao, Yan Meng,Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway".[J].Frontiers in Pharmacology,10.3389/fphar.2022.920977.[7]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J,Zhu Y, Zhu X."Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys."[J]. Front. Physiol. 12:690496.doi: 10.3389/fphys.2021.690496.

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[13]Chenyu Xu,Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."[J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324,15 pages.

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